Hvad Er De Sundhedsmæssige Fordele Og Anvendelser Af Fed Olie?

2024 Forfatter: Cecilia Ryder | [email protected]. Sidst ændret: 2023-12-17 14:20

Fedtolie ekstraheres fra fedttræet. Det er damp destilleret fra fedeknopper, der har en skarp skarp lugt. Det er hjemmehørende i Sydøstasien og er blevet brugt til at behandle smerter forbundet med tandproblemer i århundreder.

Nellikeolie siges at have antioxidante, antimikrobielle, antifungale, antiinflammatoriske og bedøvende egenskaber (1), (2). Det kan også hjælpe med at behandle hudlidelser, hjælpe fordøjelsen og øge immunforsvaret. Denne artikel diskuterer de potentielle sundhedsmæssige fordele, anvendelser og bivirkninger af fed olie. Læs videre for at vide mere.

Indholdsfortegnelse

• 12 anvendelser og fordele ved fed olie
• Andre anvendelser af fed olie
• Hvordan man bruger fed olie til at behandle tandpine?
• Hvordan bruger du fed olie til hårvækst?
• Er der nogen bivirkninger ved at bruge fed olie?
• Hvad skal man se efter, når man køber fed olie

12 anvendelser og fordele ved fed olie

1. Kan lindre tandpine

Essentiel olie med fedter kan hjælpe med at forhindre hulrum og lindre oral smerte. Traditionelt bruges det til at lindre tandpine. Det bruges også til dental nødsituationer som mund- eller halsbetændelse. Fedtolie er også rapporteret at være brugt til fremstilling af visse tandpastaer og mundskyllevand (3). Eugenol, en aromatisk olieagtig væske ekstraheret fra fed olie, bruges som beroligende middel i tandbehandlinger (4). Fed har også anti-plaque egenskaber. Det kan hæmme væksten af de orale bakterier, der kan forårsage tandplaque (5).

Essentiel olie med fedter viste sig også at udvise antikariogen og cytotoksisk aktivitet mod et stort antal orale patogener (6). Eugenol og eugenylacetat er de to aktive komponenter i fed æterisk olie, der hjælper med at forhindre afkalkning eller dental erosion (7). Fed olie er mest effektiv mod mikroorganismer, der forårsager tandkaries (8).

2. Kan hjælpe med at behandle hudsygdomme og acne

Nellikeolie siges at virke mod Propionibacterium acnes, bakterier der forårsager acne (9). Der er dog behov for flere undersøgelser i denne linje for at nå yderligere konklusioner.

En undersøgelse foretaget af Department of Dermatology, Cairo, Egypten viste, at fed olie var effektiv til topisk behandling af kronisk kløe (10).

En anden undersøgelse foretaget af Mansoura Universitetshospital, Egypten, viste, at topisk anvendelse af krydderolieolie kan hjælpe med behandlingen af kroniske analfissurer (11).

3. Kan have analgetiske egenskaber

Fedtoliemassage viste sig effektivt at reducere rygsmerter hos postnatale mødre (12). Kløverolie siges at have analgetiske egenskaber, der reducerer tandpine og ledsmerter ved at aktivere calcium- og chloridkanalerne i lymfeknuderne (13). Eugenolen i fed er også undersøgt for dets smertestillende virkning (14). Fedtolie kunne også lindre smerter hos mus (15).

En anden undersøgelse foretaget af Kuwait University viste, at fedgel kunne have potentialet til at erstatte benzocain som et aktuelt bedøvelsesmiddel (16).

4. Kan hjælpe fordøjelsen

Fedtolie kan hjælpe med at lindre kvalme, opkastning og køresyge takket være dets antiirritations- og beroligende egenskaber (17). Eugenolen i fed essentiel olie har evnen til at stimulere syntesen af slim, en vigtig gastrobeskyttende faktor (18). Imidlertid kræves yderligere forskning for at forstå dets anvendelse til behandling af mavesår.

5. Kan øge immunsystemet

Eugenolen i nelliker beskytter cellemembranerne mod beskadigelse af frie radikaler og oxidativ stress (19). I et dyreforsøg kunne olien også udøve en beskyttende rolle mod strålingsinduceret oxidativ stress (20). Kløverolie siges at have antiinflammatoriske virkninger. En undersøgelse viste, at fedolie havde en dosisafhængig antiinflammatorisk virkning på Wistar-rotter (21). Det viste sig også, at olien havde antinociceptive og antipyretiske virkninger hos mus (22).

6. Kan have antimikrobielle egenskaber

Essentiel olie af fed er en potent kilde til antimikrobielle forbindelser, der især virker mod bakterielle patogener (23). Olien kan være effektiv til at stoppe væksten af flere typer bakterier og også virke mod patogener i luftvejene (24). Fedtolie blev også fundet at virke mod de kliniske stammer af Escherichia-spolen, en specifik bakterie, der er meget resistent over for flere antibiotika (25). En undersøgelse foretaget af sektionen for mikrobiologi og teknologi i fisk og skaldyr, Spanien, viste, at fed essentiel olie effektivt dræbte Staphylococcus aureus biofilm (26).

Derudover virker fedtsolie mod Candida albicans, der forårsager oral trøske, atletfod og vaginale gærinfektioner. Eugenolen i fed olie kunne udøve en antikandidal virkning (27). En undersøgelse foretaget af Toyama Medical and Pharmaceutical University viste, at en kombination af acyclovir En undersøgelse foretaget af Toyama Medical and Pharmaceutical University viste, at en kombination af acyclovir (et antiviralt lægemiddel) og fed i mus kunne behandle herpes simplex viral infektion (28). En æterisk olieblanding med fed olie kan væsentligt dæmpe influenzavirus. Virusene behandlet med olieblandingen havde minimal ekspression af virale proteiner. Dette betyder, at fed olie kan have evnen til at bekæmpe visse vira, der forårsager infektioner (29).

7. Kan fungere som et insektmiddel

Fedtolie kan fungere som et insektmiddel og forhindre vektorbårne sygdomme (forårsaget hos mennesker af en parasit) (30). En undersøgelse viste, at komponenterne i æterisk olie med fedter potentielt kunne være nyttige i produktionen af kropslusmiddel (31). Krydderolie kunne også udvise frastødende aktivitet mod japanske termitter (32).

En undersøgelse foretaget af Mahidol University, Thailand, viste, at essentiel olie af nelliker kunne afvise Leptotrombidium chiggers, som er en art af larver. Olien kan også være et sikrere og billigere alternativ til syntetiske afstødningsmidler, der kan forårsage bivirkninger (33). Essentiel olie af fed er også afvisende mod Leptotrombidium deliense, en anden art af larver (34). Også en formulering indeholdende essentiel olie af fed blev fundet at være effektiv mod Aedes aegypti-myggen (35).

Eugenolen i fed olie kunne også fungere som et lovende alternativ til almindelige insekticider (36). Eugenol, eugenolacetat og beta-caryophyllen, de bioaktive kemikalier i fed, viste sig at have evnen til at afvise røde ildmyrer (37).

8. Kan reducere mavesmerter

Eugenolen i fed olie er blevet foreslået at være gavnlig for gastrointestinale klager, såsom mavesmerter. Det bruges også til behandling af hoste, slim og overbelastning i brystet (38). Fedt kan bruges til at reducere mavesmerter. Der er dog begrænsede data tilgængelige for at understøtte dette krav.

9. Kan øge kardiovaskulær sundhed

Fed olie kan hjælpe med at øge hjerte-kar-sundhed. Traditionelt er det kendt at forbedre blodcirkulationen. En rotteundersøgelse viste, at eugenolen i de oliedilaterede hjernearterier. Dette hos mennesker kan betyde en reduceret risiko for slagtilfælde (39). Hos rotter kunne behandling med eugenol sænke blodtryksniveauerne og endda sænke hjertefrekvensen (40). I en anden undersøgelse viste rotter med høj fructose fodring, når de fik æterisk olie med fedter, en forbedring i fedtlever. Olien kunne også regulere kolesterolniveauer i rotterne. Undersøgelsen antyder de mulige kardiobeskyttende egenskaber ved fed olie (41).

Hos diabetiske rotter kunne fed olie også vise kardiobeskyttende virkninger. Dette kan være på grund af oliens antioxidantegenskaber (42). En anden undersøgelse konkluderer, at eugenol kan være terapeutisk anvendelig som et antihypertensivt middel (43).

10. Kan fremme hårvækst

Eugenol er kendt for at stimulere hårrødderne. En formulering indeholdende fed olie blev fundet til at pleje hår og forbedre dets vækst. Det kunne reparere hårakslen (44). Der er dog behov for flere undersøgelser i denne linje for at nå yderligere konklusioner.

11. Kan have anticancer egenskaber

Eugenol blev identificeret som et af de midler, der kunne have kræftegenskaber. Det kan også forhindre spredning af kræftceller og kan hjælpe med kræftcelledød (apoptose) (45).

I en anden undersøgelse kunne eugenol undertrykke væksten af melanom eller hudkræft. Eugenol-behandling kunne reducere tumorstørrelsen med 40% og forsinkede også væksten af tumorer (46). Det nationale toksikologiprogram baseret på flere langvarige kræftfremkaldende undersøgelser konkluderede, at eugenol ikke var kræftfremkaldende for rotter (47). Lignende observationer kunne også forventes hos mennesker.

I en anden undersøgelse viste det sig, at fedekstrakt hæmmer tumorvækst. Det kan være en ny behandling for kolorektal kræft (48).

Det er dog vigtigt at udvise forsigtighed, da eugenol også kan have visse prooxidantegenskaber. Forbindelsen kan forårsage allergier og andre inflammatoriske reaktioner (49).

12. Kan fungere som et elskovsmiddel

I undersøgelser af hanmus kunne ekstrakter af fed (sammen med muskatnød) forbedre seksuel adfærd (50). I en anden undersøgelse producerede 50% ethanolekstrakt af fed en signifikant og vedvarende stigning i den seksuelle aktivitet hos normale hanrotter. Ekstrakten forårsagede heller ingen bivirkninger (51). Flere studier er dog berettigede i denne henseende.

Disse er de største fordele ved fed olie. Olien har også andre vigtige anvendelser, som vi vil undersøge i det følgende afsnit.

Andre anvendelser af fed olie

• Fedtolie blandet med kanel, appelsin, muskatnød eller vaniljeolie kan løfte ens humør. Brug af denne opvarmningsblanding i en diffusor fylder snart rummet og kan også aflaste stress.
• Anekdotiske beviser tyder på, at sniffing af krydderfrugts krydret aroma reducerer døsighed og træthed, irritabilitet og hovedpine. Det kan stimulere sindet og også øge hukommelsen.
• Nelliker tilskynder til at løsne slim fra åndedrætssystemet. De fremmer også sved under feber, forkølelse og influenza, som kan være meget helbredende. Krydderolie bruges ofte i hostemedicin.
• Ligesom mange kulinariske krydderier kan kryddernød hjælpe med at slappe af i glatte muskelforingen i fordøjelseskanalen. Et par dråber af olien i vand kan lindre kvalme. Fed te kan hjælpe med at behandle diarré, gas, oppustethed og tarmkramper.
• Fedtolie stimulerer cirkulation og blodgennemstrømning til huden. Dette kan hjælpe dem med kolde ekstremiteter.
• Fed olie er lige så effektiv som olie af oregano til behandling af fodsvamp, neglesvamp og andre hudproblemer. Det kan påføres direkte på huden eller neglene (medmindre huden er følsom eller knust, hvor den skal fortyndes med ekstra jomfru olivenolie eller uraffineret kokosnøddeolie).
• One drop of clove oil applied to the roof of the mouth may relieve headaches. However, more research is warranted in this regard.
• Clove oil is long used in aromatherapy to relieve pain. For general pain relief, add 3 drops of clove oil to 1 teaspoon of coconut oil or extra virgin olive oil. Apply it to the pain areas.
• A band-aid soaked in a few drops of clove oil can help treat warts. Applying the band-aid to warts may help dissolve them if done regularly for a few weeks.

Clove oil is popularly known as a remedy for toothache. Using oil to relieve tooth pain is simple. Check the following section

How To Use Clove Oil To Treat A Toothache?

Dentists use clove oil as an oral anesthetic and also to disinfect root canals. The oil stops the toothache when dropped into the oral cavity. For temporary relief, dip a cotton swab in clove oil and apply it to the affected tooth. Adding a clove or two to a cup of tea can work miracles on a toothache.

Here is how you can use clove oil to relieve your toothache:

• Dilute a few drops of clove oil in an edible carrier oil, such as olive or coconut oils.
• Dab a clean cotton ball into the solution, and allow it to soak in it.
• Avoiding contact with your gums, apply the cotton ball to the sore tooth. It may take a few minutes of application for you to feel the relief.
• Apply every 2 hours or as necessary.

You can use clove oil in various other ways to achieve its benefits. In the following section we have discussed its most popular uses.

How To Use Clove Oil?

Spray

Using the clove oil as a spray is an easy way to add the clove scent to your room. Clove oil possesses antimicrobial properties, and you can also use it as a mild disinfectant.

To make a clove spray:

• Add several drops of clove oil to water. You would need 10 to 15 drops of clove oil per ounce of water to prepare the spray.
• Add it to a spray bottle. Be sure to shake the bottle well before spraying.

Diffuser

You can also use the oil in a diffuser. While diffusing clove oil, carefully follow the instructions that come with the diffuser. Make sure the room is well-ventilated when you diffuse the clove oil.

Topically

You can apply clove oil to your skin to achieve different benefits.

Massage oils

Use 15 drops of clove oil per ounce of carrier oil to create a 2.5 percent solution of massage oil. This solution can be used as a massage oil for pain relief.

Creams, scrubs, or lotions

For use on normal skin, you need 1 to 2.5 percent dilution of clove oil. For sensitive skin, you need 0.5 to 1 percent dilution of the oil. This diluted solution has no aroma and can be used in the preparation of several scrubs, lotions, or creams.

How Do You Use Clove Oil For Hair Growth?

There is not enough information in this regard. But anecdotal evidence suggests that clove oil acts as a natural remedy to promote hair growth as it contains a number of vital vitamins and minerals. Massaging diluted clove oil into your scalp may boost blood circulation. This could ensure more nutrients and oxygen are supplied to your scalp and hair follicles. To experience the benefits of clove essential oil for hair growth, you can indulge in a hot oil treatment or apply a DIY hair mask prepared with clove oil.

Though clove oil is well studied for its benefits, it may not be suitable for all. The oil may cause side effects in some.

Are There Any Side Effects Of Using Clove Oil?

Clove oil may cause local irritation, rare allergic reactions, and contact dermatitis in some individuals. More severe effects include tissue injury and acute onset of seizures, coma, and damage to the liver and kidneys (52). Clove essential oil is generally recognized as a safe substance when consumed in concentrations lower than 1500 mg/kg. The World Health Organization (WHO) established that the daily quantity acceptable of clove per day is 2.5 mg for every kg of body weight in humans (53).

Hepatotoxicity

High doses of eugenol may harm the liver and kidneys, as per some rat studies. Several instances of severe acute liver and kidney injury have been reported after an accidental overdose of eugenol containing herbal products, largely in infants (54), (55).

May Cause Skin irritation

Excess usage of clove oil can cause skin irritation in some people. Eugenol is an effective substance that is incorporated into many dental products. Contact dermatitis due to this chemical is not unusual. However, true serious allergic reactions are extremely rare (56).

As a primary irritant and sensitizer, eugenol is known to cause contact urticaria as well as chronic urticaria (rashes with dangerous swelling) (57). If you are concerned about your sensitivity to this essential oil, do a patch test before using it. Apply a small amount of diluted clove oil to the inside of your elbow. If you notice signs of skin irritation, like redness, itching, or swelling, don’t use clove oil topically.

May Cause Allergies

It is very rare to have an allergic reaction due to clove oil. The eugenol in the oil may cause oral irritation and heat sensation on the tongue (58).

Drug Interactions

Medications that slow blood clotting (anticoagulant/antiplatelet drugs) interact with clove. Hence, avoid using clove oil if you are taking any anticoagulants. Acetyl eugenol, a component of clove oil (Syzygium aromaticum L.), inhibits platelet aggregation in humans. This could lead to bleeding (59), (60).

Avoid using clove oil if you have had a recent major surgery, peptic ulcers, or bleeding disorders, such as hemophilia.

You can buy clove oil from your nearest health store. But before you make a purchase, you need to keep a few things in mind.

What To Look For When Buying Clove Oil

Look for a purity statement on the label

Try to buy 100 percent clove essential oil and look for other ingredients listed (if any).

Don’t go by the marketing hype

Generally, essential oils are not regulated by the Food and Drug Administration (FDA) in the same way as drugs. Hence, you should be more cautious of any oil that claims to cure a specific condition.

Make sure the clove oil is in a dark glass bottle

Light has the potential to damage essential oils. Dark glass helps keep the light out. Always ensure your product comes packaged in a dark glass bottle.

If you can, smell it before buying it

Clove essential oil has a unique fragrance. Smell it before buying. If it does not smell natural, avoid purchasing it.

Conclusion

Clove oil possesses many therapeutic properties and has several health benefits. From dealing with dental problems to treating cardiovascular issues, this essential oil can improve human health in various ways. However, excess usage may cause several side effects. Hence, limit its use and consult your doctor if you experience any adverse effects.

Expert’s Answers For Readers’ Questions

Can you drink clove oil?

Ingestion of clove oil can be dangerous. Clove oil ingestion may result in coma, fits, and acute liver damage (61).

Can clove oil damage teeth?

Clove oil is generally considered safe for teeth.

How often can I use clove oil on my tooth?

If you are suffering from toothache, you can use it every 3-5 hours for relief. If you have multiple pain points in your mouth after a dental procedure, you can add a few drops of clove oil to coconut oil and swirl it in your mouth.

Does clove oil help you sleep?

The oil contains eugenol that is a mild anesthetic. It may aid in sleeping. Apply a few drops of warm clove oil with some carrier oil on your forehead for better sleep.

Can you apply clove oil directly to the skin?

First, do a patch test after diluting the oil with a carrier oil. If there is no reaction, you can apply clove oil to your skin.

How long does clove oil take to work?

Clove oil may soothe a toothache and relieve pain within minutes. It generally takes 5-10 minutes to work.

61 sources

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• Milind, Parle og Khanna Deepa. "Fedd: et mester krydderi." Int J Res Ayurveda Pharm 2.1 (2011): 47-54.

  www.researchgate.net/publication/267402397_Clove_A_champion_spice

• Cortés-Rojas, Diego Francisco et al. "Fed (Syzygium aromaticum): et dyrebart krydderi." Asian Pacific journal of tropical biomedicine vol. 4,2 (2014): 90-6.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/

• Kumarswamy, A. “Multimodal management of dental pain with focus on alternative medicine: A novel herbal dental gel.” Contemporary clinical dentistry vol. 7,2 (2016): 131-9.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4906852/

• Kozam, George. “The effect of eugenol on nerve transmission.” Oral Surgery, Oral Medicine, Oral Pathology 44.5 (1977): 799-805.

  www.sciencedirect.com/science/article/abs/pii/0030422077903905

• Kothiwale, Shaila V., et al. “A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse.” Journal of Indian Society of Periodontology 18.3 (2014): 316.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4095623/

• Kouidhi, Bochra, Tarek Zmantar, and Amina Bakhrouf. “Anticariogenic and cytotoxic activity of clove essential oil (Eugenia caryophyllata) against a large number of oral pathogens.” Annals of microbiology 60.4 (2010): 599-604.

  link.springer.com/article/10.1007/s13213-010-0092-6

• Marya, Charu M et al. “In vitro inhibitory effect of clove essential oil and its two active principles on tooth decalcification by apple juice.” International journal of dentistry vol. 2012 (2012): 759618.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3432374/

• Kanth, M Rajini et al. “Efficacy of Specific Plant Products on Microorganisms Causing Dental Caries.” Journal of clinical and diagnostic research: JCDR vol. 10,12 (2016): ZM01-ZM03. doi:10.7860/JCDR/2016/19772.9025

  www.ncbi.nlm.nih.gov/pmc/articles/PMC5296592/

• Fu, YuJie, et al. “The antibacterial activity of clove essential oil against Propionibacterium acnes and its mechanism of action.” Archives of dermatology 145.1 (2009): 86-88.

  jamanetwork.com/journals/jamadermatology/article-abstract/711838

• Ibrahim IM, Elsaie ML, Almohsen AM, Mohey-Eddin MH. Effectiveness of topical clove oil on symptomatic treatment of chronic pruritus. J Cosmet Dermatol. 2017;16(4):508‐511.

  pubmed.ncbi.nlm.nih.gov/28382655/

• Elwakeel HA, Moneim HA, Farid M, Gohar AA. Clove oil cream: a new effective treatment for chronic anal fissure. Colorectal Dis. 2007;9(6):549‐552.

  pubmed.ncbi.nlm.nih.gov/17573751/

• Nethravathi, V., and V. Vijaitha. “Effectiveness of Clove oil massage on Lower Back Pain among Post Natal Mothers at Selected Hospitals, Bangalore.” Asian Journal of Nursing education and research 5.4 (2015): 467-470.

  www.researchgate.net/publication/286523804_Effectiveness_of_Clove_oil_massage_on_Lower_Back_Pain_among_Post_Natal_Mothers_at_Selected_Hospitals_Bangalore

• Cortés-Rojas, Diego Francisco et al. “Clove (Syzygium aromaticum): a precious spice.” Asian Pacific journal of tropical biomedicine vol. 4,2 (2014): 90-6. doi:10.1016/S2221-1691(14)60215-X

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3819475/#b30

• Li, Hai Ying et al. “Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons.” The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 12,6 (2008): 315-21. doi:10.4196/kjpp.2008.12.6.315

  www.ncbi.nlm.nih.gov/pmc/articles/PMC2788653/

• Halder, Sumita, et al. “Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice.” Naunyn-Schmiedeberg’s archives of pharmacology 385.6 (2012): 587-593.

  link.springer.com/article/10.1007%2Fs00210-012-0742-2

• Alqareer A, Alyahya A, Andersson L. The effect of clove and benzocaine versus placebo as topical anesthetics. J Dent. 2006;34(10):747‐750.

  pubmed.ncbi.nlm.nih.gov/16530911/

• Duarte, R. C., et al. “Irradiation effect on antifungal potential of clove essential oil.” Science And Technology Against Microbial Pathogens: Research, Development and Evaluation. 2011. 236-240.

  www.worldscientific.com/doi/abs/10.1142/9789814354868_0046

• Santin JR, Lemos M, Klein-Júnior LC, et al. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol. 2011;383(2):149‐158.

  pubmed.ncbi.nlm.nih.gov/21140134/

• Kumaravelu, Parasakthy, et al. “The antioxidant effect of eugenol on CCl4-induced erythrocyte damage in rats.” The Journal of Nutritional Biochemistry 7.1 (1996): 23-28.

  www.sciencedirect.com/science/article/abs/pii/095528639500162X

• Abdel-Magied, N., and A. G. Ahmed. “Efficacy of clove oil as an antioxidant against radiation risk in male rats.” Journal of Radiation Research and Applied Sciences 4.3 (2011): 939-955.

  inis.iaea.org/search/search.aspx?orig_q=RN:44083430

• Humbal, Brijesh R., et al. “Evaluation of in-vivo anti-inflammatory activity of Syzygium aromaticum oil in male wistar rats.” (2019).

  www.researchgate.net/publication/334735954_Evaluation_of_in-vivo_anti-inflammatory_activity_of_Syzygium_aromaticum_oil_in_male_wistar_rats

• Taher, Yousef A., et al. “Experimental evaluation of anti-inflammatory, antinociceptive and antipyretic activities of clove oil in mice.” Libyan Journal of Medicine 10.1 (2015): 28685.

  www.tandfonline.com/doi/full/10.3402/ljm.v10.28685

• Nuñez, L, and M D’ Aquino. “Microbicide activity of clove essential oil (Eugenia caryophyllata).” Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology] vol. 43,4 (2012): 1255-60.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC3769004/

• Ács, Kamilla et al. “Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens.” BMC complementary and alternative medicine vol. 18,1 227. 27 Jul. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6064118/

• Santa Packyanathan, Jerusha, and Gopinath Prakasam. “Antibacterial Effect of Clove Oil against Clinical Strains of Escherichia coli.” Journal of Pharmaceutical Sciences and Research 9.7 (2017): 1203.

  search.proquest.com/openview/8bf3b96982be7f97c4f86c4dd8ae3dd9/1?pq-origsite=gscholar&cbl=54977

• Vázquez-Sánchez D, Cabo ML, Rodríguez-Herrera JJ. Antimicrobial activity of essential oils against Staphylococcus aureus biofilms. Food Sci Technol Int. 2015;21(8):559‐570.

  pubmed.ncbi.nlm.nih.gov/25280938/

• Chami N, Bennis S, Chami F, Aboussekhra A, Remmal A. Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol. 2005;20(2):106‐111.

  pubmed.ncbi.nlm.nih.gov/15720571/

• Kurokawa M, Nagasaka K, Hirabayashi T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res. 1995;27(1-2):19‐37.

  pubmed.ncbi.nlm.nih.gov/7486956/

• Wu, Shuhua et al. “Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells.” BMC complementary and alternative medicine vol. 10 69. 15 Nov. 2010.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC2994788/

• Shapiro, Rochel. “Prevention of vector transmitted diseases with clove oil insect repellent.” Journal of pediatric nursing 27.4 (2012): 346-349.

  www.sciencedirect.com/science/article/abs/pii/S0882596311001898

• Iwamatsu, Takuma, et al. “Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.” Parasitology research 115.4 (2016): 1659-1666.

  link.springer.com/article/10.1007/s00436-016-4905-9

• Park, Il-Kwon, and Sang-Chul Shin. “Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermes speratus Kolbe).” Journal of Agricultural and Food Chemistry 53.11 (2005): 4388-4392.

  pubs.acs.org/doi/abs/10.1021/jf050393r

• Eamsobhana P, Yoolek A, Kongkaew W, et al. Laboratory evaluation of aromatic essential oils from thirteen plant species as candidate repellents against Leptotrombidium chiggers (Acari: Trombiculidae), the vector of scrub typhus. Exp Appl Acarol. 2009;47(3):257‐262.

  pubmed.ncbi.nlm.nih.gov/19009361/

• Hanifah, Azima Laili, et al. “Laboratory evaluation of six crude plant extracts as repellents against larval Leptotrombidium deliense (Acari: Trombiculidae).” Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S257-S259.

  www.sciencedirect.com/science/article/abs/pii/S2221169112601701

• Sritabutra, Duangkamon, et al. “Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton & Harrion.” Asian Pacific Journal of Tropical Biomedicine 1.1 (2011): S124-S128.

  www.sciencedirect.com/science/article/abs/pii/S222116911160138X

• Barbosa, Juliana DF, et al. “Structure–activity relationships of eugenol derivatives against Aedes aegypti (Diptera: Culicidae) larvae.” Pest management science 68.11 (2012): 1478-1483.

  onlinelibrary.wiley.com/doi/abs/10.1002/ps.3331

• Kafle L, Shih CJ. Toxicity and repellency of compounds from clove (Syzygium aromaticum) to red imported fire ants Solenopsis invicta (Hymenoptera: Formicidae). J Econ Entomol. 2013;106(1):131‐135.

  pubmed.ncbi.nlm.nih.gov/23448024/

• Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil) [Updated 2019 Oct 28].

  www.ncbi.nlm.nih.gov/books/NBK551727/

• Peixoto-Neves, Dieniffer et al. “Eugenol dilates rat cerebral arteries by inhibiting smooth muscle cell voltage-dependent calcium channels.” Journal of cardiovascular pharmacology vol. 64,5 (2014): 401-6.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4224997/

• Lahlou, Saad, et al. “Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.” Journal of cardiovascular pharmacology 43.2 (2004): 250-257.

  www.researchgate.net/publication/8925226_Cardiovascular_Effects_of_Eugenol_A_Phenolic_Compound_Present_in_Many_Plant_Essential_Oils_in_Normotensive_Rats

• Al-Okbi, Sahar Y., et al. “Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome.” Journal of medicinal food 17.7 (2014): 764-771.

  pubmed.ncbi.nlm.nih.gov/24611461/

• Shukri, Radhiah, Suhaila Mohamed, and Noordin Mohamed Mustapha. “Cloves protect the heart, liver and lens of diabetic rats.” Food chemistry 122.4 (2010): 1116-1121.

  www.sciencedirect.com/science/article/abs/pii/S0308814610003870

• Peixoto‐Neves, Dieniffer, et al. “Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV 4 channels.” British journal of pharmacology 172.14 (2015): 3484-3494.

  pubmed.ncbi.nlm.nih.gov/25832173/

• Shahtalebi, Mohammad Ali, Atefeh Sadat-Hosseini, and Leila Safaeian. “Preparation and evaluation of clove oil in emu oil self-emulsion for hair conditioning and hair loss prevention.” Journal of HerbMed Pharmacology 5 (2016).

  www.researchgate.net/publication/301204003_Preparation_and_evaluation_of_clove_oil_in_emu_oil_self-emulsion_for_hair_conditioning_and_hair_loss_prevention

• Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006;71(10):1397‐1421.

  pubmed.ncbi.nlm.nih.gov/16563357/

• Ghosh, Rita, et al. “Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity.” Journal of Biological Chemistry, 18 Feb. 2005, www.jbc.org/content/280/7/5812.short.

• National Toxicology Program. Carcinogenesis Studies of Eugenol (CAS No. 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1983;223:1‐159.

  pubmed.ncbi.nlm.nih.gov/12778213/

• Liu, Haizhou et al. “Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis.” Oncology research vol. 21,5 (2014): 247-59.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC4132639/

• Atsumi, T., et al. “A Comparative Study of the Antioxidant/Prooxidant Activities of Eugenol and Isoeugenol with Various Concentrations and Oxidation Conditions.” Toxicology in Vitro, Pergamon, 17 June 2005, www.sciencedirect.com/science/article/abs/pii/S088723330500072X.

  www.citationmachine.net/bibliographies/616422860?new=true

• Tajuddin et al. “Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study.” BMC complementary and alternative medicine vol. 3 6. 20 Oct. 2003.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC270058/

• Tajuddin et al. “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats.” BMC complementary and alternative medicine vol. 4 17. 5 Nov. 2004.

  www.ncbi.nlm.nih.gov/pmc/articles/PMC534794/

• Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Eugenol (Clove Oil) [Updated 2019 Oct 28].

  www.ncbi.nlm.nih.gov/books/NBK551727/

• Gülçin, İlhami, et al. “Antioxidant Activity of Clove Oil – A Powerful Antioxidant Source.” Arabian Journal of Chemistry, Elsevier, 19 Sept. 2010, www.sciencedirect.com/science/article/pii/S1878535210001899.

• Thompson DC, Constantin-Teodosiu D, Moldéus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem Biol Interact. 1991;77(2):137‐147.

  pubmed.ncbi.nlm.nih.gov/1991333/

• Mizutani T, Satoh K, Nomura H, Nakanishi K. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol. 1991;71(2):219‐230.

  pubmed.ncbi.nlm.nih.gov/2047567/

• Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol. 1984;57(4):441‐442.

  pubmed.ncbi.nlm.nih.gov/6584843/

• Tammannavar P, Pushpalatha C, Jain S, Sowmya SV. An unexpected positive hypersensitive reaction to eugenol. BMJ Case Rep. 2013;2013:bcr2013009464. Published 2013 Sep 18.

  pubmed.ncbi.nlm.nih.gov/24049087/

• Klein AH, Carstens MI, Carstens E. Eugenol and carvacrol induce temporally desensitizing patterns of oral irritation and enhance innocuous warmth and noxious heat sensation on the tongue. Pain. 2013;154(10):2078‐2087.

  pubmed.ncbi.nlm.nih.gov/23791894/

• Srivastava, K. C., and N. Malhotra. “Acetyl Eugenol, a Component of Oil of Cloves (Syzygium Aromaticum L.) Inhibits Aggregation and Alters Arachidonic Acid Metabolism in Human Blood Platelets.” Prostaglandins, Leukotrienes and Essential Fatty Acids, Churchill Livingstone, 3 Apr. 2004.

  www.sciencedirect.com/science/article/abs/pii/095232789190070L

• Srivastava, K. C. “Antiplatelet Principles from a Food Spice Clove (Syzgium Aromaticum L).” Prostaglandins, Leukotrienes and Essential Fatty Acids, Churchill Livingstone, 3 Apr. 2004.

  www.sciencedirect.com/science/article/abs/pii/095232789390116E

• Hartnoll G, Moore D, Douek D. Near fatal ingestion of oil of cloves. Arch Dis Child. 1993;69(3):392‐393.

  pubmed.ncbi.nlm.nih.gov/8215554/